Cancer chemopreventive agents, labdane diterpenoids from the stem bark of Thuja standishii (Gord.) Carr.

Abstract

Seven labdane-type diterpenoids from the stem bark of Thuja standishii (Gord.) Carr. (Cupressaceae) and their analogues showed strong inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Among these compounds, 15,16-bisnor-13-oxolabda-8(17), 11E-dien-19-oic acid was revealed to have the strongest inhibitory effect on the EBV-EA activation, being stronger than that of beta-carotene which has been intensively studied in cancer prevention using animal models. 15,16-bisnor-13-Oxolabda-8(17), 11E-dien-19-oic acid was also found to exhibit the excellent anti-tumor promoting activity in two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene and TPA.

• Authors: R Tanaka, H Ohtsu, M Iwamoto, T Minami, H Tokuda, H Nishino, S Matsunaga, A Yoshitake
• Journal: Cancer letters (Cancer Lett) Vol. 161 Issue 2 Pg. 165-70 (Dec 20 2000) ISSN: 0304-3835 [Print] Ireland
• PMID: 11090965 (Publication Type: Journal Article)

Chemical References

• 15,16-bisnor-13-oxolabda-8(17),11-dien-19-oic acid
• Antigens, Viral
• Carboxylic Acids
• Carcinogens
• Diterpenes
• Epstein-Barr virus early antigen
• Naphthalenes
• Plant Extracts
• beta Carotene
• 9,10-Dimethyl-1,2-benzanthracene
• Tetradecanoylphorbol Acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Antigens, Viral (metabolism)
• Carboxylic Acids (chemistry, pharmacology)
• Carcinogens
• Diterpenes (chemistry, pharmacology)
• Female
• Humans
• Mice
• Mice, Inbred ICR
• Naphthalenes (chemistry, pharmacology)
• Nasopharyngeal Neoplasms (prevention & control)
• Neoplasms (prevention & control)
• Papilloma (prevention & control)
• Plant Extracts (chemistry, pharmacology)
• Plant Stems
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate
• Trees
• beta Carotene (pharmacology)