Abstract | OBJECTIVE: METHODS: A total of 3027 adult patients undergoing elective coronary artery bypass grafting, valve operations, or both were randomized to a single dose of teicoplanin (15 mg/kg) or a 2-day course of cefazolin (2 g initial dose, followed by 1 g every 8 hours for 6 more doses). Patients were followed up for a total of 6 months postoperatively. The primary objective was to compare, between groups, the incidence of surgical infections up to 30 days postoperatively. Secondary objectives were incidence of other infections, other complications, and death. RESULTS: CONCLUSIONS:
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Authors | R Saginur, D Croteau, M G Bergeron |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 120
Issue 6
Pg. 1120-30
(Dec 2000)
ISSN: 0022-5223 [Print] United States |
PMID | 11088036
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Cephalosporins
- Teicoplanin
- Cefazolin
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(pharmacokinetics, therapeutic use)
- Antibiotic Prophylaxis
(methods)
- Bacterial Infections
(etiology, mortality, prevention & control)
- Canada
(epidemiology)
- Cefazolin
(pharmacokinetics, therapeutic use)
- Cephalosporins
(pharmacokinetics, therapeutic use)
- Coronary Artery Bypass
(adverse effects)
- Double-Blind Method
- Drug Resistance, Microbial
- Female
- Follow-Up Studies
- Heart Valve Prosthesis Implantation
(adverse effects)
- Humans
- Incidence
- Male
- Middle Aged
- Morbidity
- Surgical Wound Infection
(etiology, mortality, prevention & control)
- Teicoplanin
(pharmacokinetics, therapeutic use)
- Treatment Outcome
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