Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex.

Abstract	Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and control subjects and hierarchical data analysis revealed that transcripts encoding proteins involved in the regulation of presynaptic function (PSYN) were decreased in all subjects with schizophrenia. Genes of the PSYN group showed a different combination of decreased expression across subjects. Over 250 other gene groups did not show altered expression. Selected PSYN microarray observations were verified by in situ hybridization. Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model.
Authors	K Mirnics, F A Middleton, A Marquez, D A Lewis, P Levitt
Journal	Neuron (Neuron) Vol. 28 Issue 1 Pg. 53-67 (Oct 2000) ISSN: 0896-6273 [Print] United States
PMID	11086983 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antipsychotic Agents Carrier Proteins RNA, Messenger Synapsins Vesicular Transport Proteins N-Ethylmaleimide-Sensitive Proteins
Topics	Animals Antipsychotic Agents (pharmacology) Carrier Proteins (genetics, metabolism) Confounding Factors, Epidemiologic Female Gene Expression (drug effects) Gene Expression Profiling Genetic Variation (genetics) Humans In Situ Hybridization Macaca fascicularis Male Middle Aged N-Ethylmaleimide-Sensitive Proteins Oligonucleotide Array Sequence Analysis Prefrontal Cortex (chemistry, metabolism) Presynaptic Terminals (metabolism, pathology) RNA, Messenger (analysis, metabolism) Schizophrenia (epidemiology, genetics, metabolism) Synapses (metabolism) Synapsins (genetics, metabolism) Synaptic Transmission (genetics) Vesicular Transport Proteins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!