Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation.

Abstract

Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 microg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.

• Authors: S S Lim, S H Jung, J Ji, K H Shin, S R Keum
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 48 Issue 11 Pg. 1786-9 (Nov 2000) ISSN: 0009-2363 [Print] Japan
• PMID: 11086916 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Inhibitors
• Platelet Aggregation Inhibitors
• Chalcone
• Aldehyde Reductase

Topics

• Aldehyde Reductase (antagonists & inhibitors)
• Animals
• Chalcone (analogs & derivatives, pharmacology)
• Enzyme Inhibitors (pharmacology)
• In Vitro Techniques
• Lens, Crystalline (drug effects, enzymology)
• Male
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology)
• Rats
• Rats, Sprague-Dawley