[Transcatheter arterial chemo-embolization using degradable starch microspheres (DSM) markedly effective for post-hepatectomy intra-hepatic recurrence in a patient with cholangioma].

Abstract

Transcatheter arterial chemo-embolization (TACE) using degradable starch microspheres (DSM) was performed for multiple recurrence after hepatectomy in a patient with cholangiocarcinoma. The patient was a 68-year-man. He received treatment for hepatitis type C starting in 1996 at a nearby hospital. In November 1997, an increased AFP level was noted and a CT scan of the abdomen revealed an abnormal shadow in the liver. On May 21, 1998, imaging results led to the diagnosis of cholangiocarcinoma or a mixed type of hepatocellular carcinoma with cholangioma. Hepatic S7 sub-sequential resection was performed. The lesion was found to be a tumor-forming type, measuring 2.2 x 2.0 cm in diameter, diagnosed histopathologically as cholangiocarcinoma, tw (-), but Stage III since a nodule suggesting intrahepatic metastasis was noted in the cut surface of the resected liver. CT scan after a month revealed multiple metastatic lesions in the liver. TACE was performed by administering 450 mg of DSM, 10 mg of MMC and 30 mg of FARM, given in three divided doses on October 30, 1998, and February 9, 1999, according to Seldinger's method. A CT scan on January 31, 2000 revealed nearly complete remission of the hepatic SOL. Accordingly, TACE was considered to be useful therapy in combination with DSM, MMC and FARM for intrahepatic recurrence of cholangiocarcinoma.

• Authors: T Niinobu, T Shibata, Y Fukushima, M Kitada, Y Tukahara, S Hata, K Ikeda, H Hayashida, J Fuzita, Y Takahashi, T Nakamura, R Suzuki, T Shimano, M Takami, T Ishida
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 27 Issue 12 Pg. 1931-5 (Oct 2000) ISSN: 0385-0684 [Print] Japan
• PMID: 11086448 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Epirubicin
• Mitomycin
• Starch

Topics

• Aged
• Antibiotics, Antineoplastic (administration & dosage)
• Bile Duct Neoplasms (pathology)
• Bile Ducts, Intrahepatic
• Carcinoma, Hepatocellular (secondary, therapy)
• Chemoembolization, Therapeutic
• Cholangiocarcinoma (secondary, therapy)
• Epirubicin (administration & dosage)
• Hepatectomy
• Humans
• Liver Neoplasms (secondary, surgery, therapy)
• Male
• Microspheres
• Mitomycin (administration & dosage)
• Neoplasm Recurrence, Local
• Postoperative Period
• Starch