A 55-year-old man had a
metastasis in segment 3 of the liver 5 months after surgery for non-functioning
islet cell carcinoma of the pancreas. The metastatic lesion increased in size in a short period, and other liver micro-
metastases that could not be detected by imaging may exist, so hepatic arterial infusion
chemotherapy was scheduled for 3 months. The patient underwent hepatic arterial infusion
chemotherapy of
5-fluorouracil (250 mg/day/body for 5 days/week) and
adriamycin (10 mg/day/body for 2 days/week) and
cisplatin (10 mg/day/body for 5 days/week) and he was put on
Leucovorin 30 mg/day as a biochemical modulator of
5-FU and
tamoxifen 40 mg/day as a biochemical modulator of ADM. A total 6,000 mg of
5-FU, 100 mg of ADM and 240 mg of CDDP had been administered, until hepatic arterial infusion
chemotherapy was discontinued because of complicated
gastric ulcer. Three months later, the size of the metastatic liver
tumor was reduced remarkably and no other
metastasis was detected on CT scan, so he underwent partial
hepatectomy of the metastatic lesion. No recurrence was found and he has survived in good physical condition during the follow-up period of 5 months after the second operation.