| Abstract | Tissue factor pathway inhibitor (TFPI) fractions and coagulation markers were determined in 26 patients with disseminated intravascular coagulation (DIC). Thrombin-antithrombin complex and fibrin monomer values were markedly elevated in all patients (P < 0.01). The median TFPI activity level (2.1 nmol/l) was lower than in normal controls (2.6 nmol/l; P < 0.01). The median free TFPI level was within the normal reference range, but seven patients had levels above and nine patients had levels below normal range. The median activated factor X (FXa)-TFPI complex level in patients (0.13 nmol/l) was lower than in controls (0.18 nmol/l; P < 0.01). Only one patient had a FXa-TFPI complex level above the normal range, while eight patients had levels below. In conclusion, TFPI activity, free TFPI antigen and FXa-TFPI complex levels vary considerably in DIC. Activation of coagulation may increase TFPI levels, as reported by other workers and supported by a positive correlation between tissue factor and free TFPI in the present material. A negative correlation between fibrin monomer and free TFPI (r = -0.46, P = 0.019) might indicate that hyperactive coagulation leads to consumption of TFPI. Subnormal FXa-TFPI levels in DIC, possibly caused by consumption, may imply a reduced capacity to inactivate the triggering factor VIIa-tissue factor complex. |
| Authors | N Iversen, F G Strekerud, U Abildgaard
(Affiliation: Haematological Research Laboratory, Aker University Hospital, Oslo, Norway.)
|
| Journal | Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
(Blood Coagul Fibrinolysis)
Vol. 11
Issue 7
Pg. 591-8
(Oct 2000)
ISSN: 0957-5235 ENGLAND |
| PMID | 11085278
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anticoagulants
- Lipoproteins
- lipoprotein-associated coagulation inhibitor
- Factor Xa
|
| Topics |
- Adult
- Anticoagulants
(blood, metabolism)
- Cohort Studies
- Disseminated Intravascular Coagulation
(blood, etiology)
- Factor Xa
(metabolism)
- Female
- Humans
- Inflammation
(blood, complications)
- Lipoproteins
(blood, metabolism)
- Male
- Middle Aged
- Neoplasms
(blood, complications)
- Pregnancy
- Pregnancy Complications, Hematologic
(blood)
- Protein Binding
- Sepsis
(blood, complications)
- Statistics, Nonparametric
- Thrombophilia
(blood)
|
