| Abstract | Plasma levels of tissue factor pathway inhibitor (TFPI)-activated factor Xa (FXa) complex were measured in patients with disseminated intravascular coagulation (DIC), pre-DIC, and DIC. Plasma levels of plasmin-plasmin inhibitor complex (PPIC), D-dimer, and soluble fibrin monomer (SFM) were significantly higher in patients with DIC than in those with pre-DIC or non-DIC; the levels of these hemostatic markers were significantly higher in patients with pre-DIC than in those with non-DIC. Plasma levels of thrombin-antithrombin complex (TAT) were significantly higher in patients with DIC or pre-DIC than in those with non-DIC. Plasma levels of tissue factor (TF), total TFPI, free TFPI, and TFPI-Xa complex were significantly higher in patients with DIC than in those with non-DIC. Plasma levels of TFPI-Xa complex were significantly increased in patients with pre-DIC as compared to those with non-DIC; however, plasma free TFPI levels were significantly decreased in patients with pre-DIC as compared to those with non-DIC. These findings suggest that free TFPI might be consumed in the pre-DIC state, thereby confirming the activation of the extrinsic pathway. Plasma levels of TFPI-Xa complex were significantly correlated with TF, free TFPI, and total TFPI. Increased plasma TFPI-Xa complex levels might be useful for the diagnosis of DIC or pre-DIC, particularly that occurring by activation of the extrinsic pathway of blood coagulation. |
| Authors | Y Okugawa, H Wada, T Noda, M Sakakura, T Nakasaki, R Watanabe, H Deguchi, E C Gabazza, Y Mori, M Nishikawa, K Deguchi, T Nobori, H Shiku
(Affiliation: Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Mie-ken, Japan.)
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| Journal | American journal of hematology
(Am J Hematol)
Vol. 65
Issue 3
Pg. 210-4
(Nov 2000)
ISSN: 0361-8609 UNITED STATES |
| PMID | 11074537
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anticoagulants
- Fibrinolytic Agents
- Lipoproteins
- lipoprotein-associated coagulation inhibitor
- Factor Xa
|
| Topics |
- Anticoagulants
(metabolism)
- Disseminated Intravascular Coagulation
(blood)
- Enzyme-Linked Immunosorbent Assay
- Factor Xa
(antagonists & inhibitors, metabolism)
- Fibrinolytic Agents
(metabolism)
- Humans
- Lipoproteins
(metabolism)
|
