Abstract | BACKGROUND: An experimental model in rats was developed to investigate the significance of mucosal integrity in abacterial prostatitis. METHODS: RESULTS: Prostates subjected to ethanol plus DNBS showed significant inflammation, most notably after 12, 24, and 48 hr. Inflammation judged by gross and histological observations and interleukin-1beta levels correlated well at these times. Rats given only ethanol, DNBS, or no treatment, acting as negative controls, displayed little or no inflammation; rats given a bacterial suspension, acting as positive controls, showed inflammation consistent with past studies. Cytokine assays revealed raised interleukin-1beta levels in this model, while tumor necrosis factor-alpha remained at a basal level. CONCLUSIONS:
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Authors | M D Lang, J C Nickel, M E Olson, S R Howard, H Ceri |
Journal | The Prostate
(Prostate)
Vol. 45
Issue 3
Pg. 201-6
(Nov 01 2000)
ISSN: 0270-4137 [Print] United States |
PMID | 11074521
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2000 Wiley-Liss, Inc. |
Chemical References |
- Benzenesulfonates
- Central Nervous System Depressants
- dinitrobenzenesulfonic acid
- Ethanol
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Topics |
- Animals
- Benzenesulfonates
(administration & dosage, adverse effects)
- Central Nervous System Depressants
(administration & dosage, adverse effects)
- Disease Models, Animal
- Ethanol
(administration & dosage, adverse effects)
- Inflammation
- Male
- Mucous Membrane
(pathology)
- Prostatitis
(chemically induced, physiopathology)
- Rats
- Rats, Sprague-Dawley
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