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[Combined treatment of thymoma. State of the art and our experience].

Abstract
Thymoma is the most common neoplasm of the anterior mediastinum and is frequently associated with paraneoplastic syndromes. Surgery is the first therapeutic option, but in advanced disease a multidisciplinary approach is feasible, because of chemosensitivity and radiosensitivity of the disease. The natural history of thymoma after surgery points to local recurrence. Adjuvant radiotherapy seems to improve local control and survival. Chemotherapy based on cisplatin plus anthracyclines could be performed in advanced and metastatic disease. The optimal sequence of chemotherapy, radiation therapy and surgery is yet to be defined. In our experience, primary chemotherapy seems to give best results in advanced thymoma with good tolerability.
AuthorsD Traficante, F Longo, G Mansueto, M Salerno, R Scirocchi, L De Petris, P Marchei
JournalRecenti progressi in medicina (Recenti Prog Med) Vol. 91 Issue 10 Pg. 513-6 (Oct 2000) ISSN: 0034-1193 [Print] Italy
Vernacular TitleTrattamento integrato del timoma. Stato dell'arte e nostra esperienza.
PMID11072740 (Publication Type: Editorial, English Abstract, Review)
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Combined Modality Therapy
  • Humans
  • Neoplasm Staging
  • Radiotherapy
  • Thymectomy
  • Thymoma (pathology, therapy)
  • Thymus Neoplasms (pathology, therapy)

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