Abstract | BACKGROUND: METHODS AND RESULTS: An open-label, single-dose, escalating drug- and light-dose study was performed in patients with atherosclerotic peripheral arterial insufficiency. Clinical evaluation, serial quantitative angiography, and intravascular ultrasonography were performed. Therapy was well tolerated, and only minor side effects were observed. Treatment produced no deleterious vascular effects. Although this study was not designed to examine clinical efficacy, several secondary end points suggested a favorable therapeutic effect. CONCLUSIONS: This phase I study demonstrates that photoangioplasty with motexafin lutetium is well tolerated and safe. Preliminary efficacy data suggest a future role for the treatment of flow-limiting atherosclerosis.
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Authors | S G Rockson, P Kramer, M Razavi, A Szuba, S Filardo, P Fitzgerald, J P Cooke, S Yousuf, A R DeVault, M F Renschler, D C Adelman |
Journal | Circulation
(Circulation)
Vol. 102
Issue 19
Pg. 2322-4
(Nov 07 2000)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11067782
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Humans
- Peripheral Vascular Diseases
(drug therapy)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(therapeutic use)
- Ultrasonography
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