Histocompatibility antigen (HLA) associations with multiple sclerosis in Iran.

Abstract

Human leukocyte antigen (HLA) types were obtained from 79 Iranian patients with multiple sclerosis and compared with 100 controls. The prevalence of HLA-A24 (30.3% versus 18.0%), HLA-DR2 (43.0% versus 28. 0%) and HLA-DR15 (36.7% versus 23.0%) were significantly increased in multiple sclerosis patients compared with controls. However age at onset, and disease status (relapsing - remitting or primary progressive) did not show an association with any particular HLA type. Multiple Sclerosis (2000) 6 317 - 319

• Authors: H Kalanie, M Kamgooyan, H Sadeghian, A R Kalanie
• Journal: Multiple sclerosis (Houndmills, Basingstoke, England) (Mult Scler) Vol. 6 Issue 5 Pg. 317-9 (Oct 2000) ISSN: 1352-4585 [Print] England
• PMID: 11064440 (Publication Type: Journal Article)

Chemical References

• HLA-A Antigens
• HLA-A24 Antigen
• HLA-DR Antigens
• HLA-DR Serological Subtypes
• HLA-DR15 antigen
• HLA-DR2 Antigen

Topics

• Adolescent
• Adult
• Age of Onset
• B-Lymphocytes (immunology)
• Female
• Genetic Predisposition to Disease
• HLA-A Antigens (analysis, immunology)
• HLA-A24 Antigen
• HLA-DR Antigens (analysis, immunology)
• HLA-DR Serological Subtypes
• HLA-DR2 Antigen (analysis, immunology)
• Humans
• Iran (epidemiology)
• Male
• Middle Aged
• Multiple Sclerosis, Relapsing-Remitting (epidemiology, genetics, immunology)