Abstract | PURPOSE: The prothrombotic state that occurs in uremic patients may increase their cardiovascular risk. We studied hypertensive patients with mild-to-moderate impairment of renal function to determine if they had evidence of abnormalities in the coagulation system. SUBJECTS AND METHODS: RESULTS: Impaired renal function, defined as a creatinine clearance of 30 to 89 mL per minute per 1.73 m(2) of body surface area, was found in 168 (44%) of the patients. Age, blood pressure, duration of hypertension, and plasma levels of fibrinogen, D-dimer, prothrombin fragment 1 + 2, and lipoprotein(a) were significantly greater in these patients than in those with normal renal function; these differences persisted after adjustment for potential confounders. Creatinine clearance was significantly and inversely correlated with levels of plasma fibrinogen (Spearman's rho = -0.26, P <0.001), D-dimer (rho = -0.33, P <0.001), and prothrombin fragment 1 + 2 (rho = -0.20, P <0.001). Levels of plasma fibrinogen (P = 0.009) and D-dimer (P = 0.003) were correlated with renal function independent of age, blood pressure, duration of hypertension, triglyceride level, urinary protein excretion, and erythrocyte sedimentation rate. Lipoprotein(a) levels were correlated with fibrinogen (rho = 0.16, P = 0.003) and D-dimer (rho = 0.26, P <0.001) levels. CONCLUSIONS:
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Authors | C Catena, L Zingaro, D Casaccio, L A Sechi |
Journal | The American journal of medicine
(Am J Med)
Vol. 109
Issue 7
Pg. 556-61
(Nov 2000)
ISSN: 0002-9343 [Print] United States |
PMID | 11063957
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fibrin Fibrinogen Degradation Products
- Lipoprotein(a)
- Peptide Fragments
- Protein Precursors
- fibrin fragment D
- prothrombin fragment 1
- prothrombin fragment 2
- Antithrombin III
- Prothrombin
- Fibrinogen
- Creatinine
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Topics |
- Adult
- Aged
- Albuminuria
(blood, urine)
- Antithrombin III
(metabolism)
- Blood Coagulation Disorders
(blood, complications, urine)
- Creatinine
(blood, urine)
- Female
- Fibrin Fibrinogen Degradation Products
(metabolism)
- Fibrinogen
(metabolism)
- Humans
- Hypertension
(blood, complications, urine)
- Kidney Function Tests
- Lipoprotein(a)
(blood)
- Male
- Peptide Fragments
(metabolism)
- Platelet Count
- Protein Precursors
(metabolism)
- Prothrombin
(metabolism)
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