Assessment of proliferation index with MIB-1 as a prognostic factor in radiation therapy for cervical cancer.

Abstract

OBJECTIVES:

The relationship between the expression of murine monoclonal antibody MIB-1, which reacts with Ki-67 nuclear antigen, a marker for proliferating cells, and the prognosis of stage IIIb cervical cancer after radiation therapy was analyzed.

METHODS:

A total of 67 patients with stage IIIb cervical cancer who had received radiation therapy were included in the retrospective study. The labeled streptavidin-biotin method was used for immunohistochemical staining of the MIB-1 protein.

RESULTS:

In 32 patients showing a high MIB-1 index (percentage of cells labeled with MIB-1 >/=26.4%), the cumulative 5- and 8-year survival rates were 75.8 and 61.5%, respectively, significantly better (P < 0.05) than those in 35 patients with a low MIB-1 index (<26.4%) (59.6 and 41.1%, respectively). Serum squamous cell carcinoma antigen levels, an index of the response to radiation therapy, decreased to </=2.0 ng/mL in 100 and 68% of patients in the high and low MIB-1 index groups, respectively (P < 0.05).

CONCLUSION:

These results indicate that MIB-1 antigen may be effective in predicting the sensitivity of cervical cancer to radiation therapy and stage IIIb cervical cancer prognosis.

• Authors: M Suzuki, S Tsukagoshi, Y Saga, M Ohwada, I Sato
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 79 Issue 2 Pg. 300-4 (Nov 2000) ISSN: 0090-8258 [Print] United States
• PMID: 11063661 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright 2000 Academic Press.

Chemical References

• Antibodies, Monoclonal
• Antigens, Neoplasm
• Antigens, Nuclear
• Biomarkers, Tumor
• Ki-67 Antigen
• Nuclear Proteins
• Serpins
• squamous cell carcinoma-related antigen

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal (biosynthesis, immunology)
• Antigens, Neoplasm (blood)
• Antigens, Nuclear
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (biosynthesis, blood, immunology)
• Cell Division (immunology)
• Chemotherapy, Adjuvant
• Female
• Humans
• Ki-67 Antigen (immunology)
• Middle Aged
• Nuclear Proteins (biosynthesis, immunology)
• Prognosis
• Retrospective Studies
• Serpins
• Survival Analysis
• Uterine Cervical Neoplasms (immunology, pathology, radiotherapy)