The effect of topical delivery of novel bisacylphosphonates in reducing alveolar bone loss in the rat model.

Abstract

BACKGROUND:

Periodontal surgery stimulates osteoclast activity, leading to varying amounts of alveolar crest loss. We have established that topical application of 20 mg/ml of alendronate placed at the surgical mucoperiosteal site produced a striking reduction of alveolar bone loss in the rat model. The aim of this investigation was to examine the antiresorptive efficacy of 3 novel bisacylphosphonates topically delivered at the surgical site, in comparison to alendronate and etidronate which are in clinical use.

METHODS:

Mucoperiosteal flap (MF) surgery was performed on the buccal and lingual aspects next to molars on both sides of the rat mandible. A gelatin sponge soaked in the bisphosphonate solution prepared by dissolving 20 mg of the bisphosphonate (alendronate, etidronate, VS-5, VS-6, ISA-13, SuBP) in 1 ml of saline was applied to exposed bone on the right side of the mandible (experimental, MF + BPs ) and the left side was treated with saline only (control, MF + S). Sections were evaluated for bone loss using microradiography pattern and amount.

RESULTS:

The 3 novel bisacylphosphonates, VS-5 VS-6, and ISA-13 were more effective than etidronate, and less effective than alendronate. The most effective among this group was ISA-13 followed by VS-5 and VS-6.

CONCLUSION:

We conclude that ISA-13-like alendronate is effective in reducing alveolar bone loss when delivered at surgical sites. Since ISA-13 is well absorbed through mucose tissues, we suggest that ISA-13 efficacy on reducing bone loss should be tested by its application on the mucosal tissue.

• Authors: A Yaffe, G Golomb, E Breuer, I Binderman
• Journal: Journal of periodontology (J Periodontol) Vol. 71 Issue 10 Pg. 1607-12 (Oct 2000) ISSN: 0022-3492 [Print] United States
• PMID: 11063394 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diphosphonates
• Heterocyclic Compounds
• suberoylbisphosphonic acid
• Etidronic Acid
• Alendronate

Topics

• Administration, Topical
• Alendronate (administration & dosage)
• Alveolar Bone Loss (diagnostic imaging, prevention & control)
• Alveolar Process (diagnostic imaging, drug effects)
• Animals
• Chi-Square Distribution
• Diphosphonates (administration & dosage)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Etidronic Acid (administration & dosage)
• Heterocyclic Compounds (administration & dosage)
• Microradiography
• Multivariate Analysis
• Rats
• Rats, Wistar