Abstract | OBJECTIVE AND IMPORTANCE: CLINICAL PRESENTATION: INTERVENTION: After the inspired oxygen concentration was increased to 100% (both episodes) and the positive end expiratory pressure was increased to 7.5 mm Hg (first episode), the arterial oxygen saturation of the patient returned to baseline levels (>99%) within 40 minutes in each instance. Nimodipine therapy was discontinued after each episode. CONCLUSION: It is hypothesized that, in the presence of concomitant adult respiratory distress syndrome, nimodipine increased ventilation/perfusion ratio mismatch, through its direct vasodilatory effects on the pulmonary artery, and possibly interfered with the reflex hypoxic pulmonary vasoconstriction necessary to maintain adequate oxygenation for this patient. Clinicians should carefully monitor the oxygenation status of patients when nimodipine therapy is initiated.
|
Authors | J W Devlin, W M Coplin, K R Murry, S S Rengachary, R F Wilson |
Journal | Neurosurgery
(Neurosurgery)
Vol. 47
Issue 5
Pg. 1243-6; discussion 1246-7
(Nov 2000)
ISSN: 0148-396X [Print] United States |
PMID | 11063120
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Calcium Channel Blockers
- Nimodipine
|
Topics |
- Acute Disease
- Calcium Channel Blockers
(administration & dosage, adverse effects)
- Drug Administration Schedule
- Humans
- Hydrocephalus
(complications, diagnosis)
- Hypoxia
(chemically induced)
- Male
- Middle Aged
- Nimodipine
(administration & dosage, adverse effects)
- Subarachnoid Hemorrhage
(complications, diagnosis, drug therapy)
- Tomography, X-Ray Computed
|