Abstract |
We examined the effects of TAC-101 on the invasion and metastasis of human non-small cell lung cancer (NSCLC) cell lines. TAC-101 showed an ability to inhibit in vitro invasiveness of NSCLC at a non-cytotoxic concentration range of 3-10 microM; such concentration levels were easily achievable following oral administration of therapeutically effective doses. The inhibition of cell invasion at 10 microM of TAC-101 accounted for 58-69% when compared with control cells. Oral administration of TAC-101 (4 mg/kg/day) to mice bearing lung implanted A549 lung cancer resulted in significant life-prolonging effect (T/C: 143%). More pronounced life-prolonging effect was observed in the experimental liver metastasis model of A549, where T/C of 215% was observed following administration at 4 mg/kg/day of TAC-101. However, TAC-101 did not show the direct anti- tumor effect against the established A549 tumor xenografts after subcutaneous implantation. These findings suggest that TAC-101 interferes with cell-to-cell interaction processes leading, for instance, to the inhibition of the invasion of NSCLC cells. Taking into account the pharmacological properties of TAC-101, it is expected that TAC-101 may be a suitable candidate drug for the treatment of lung cancer patients, especially those with a predictable metastasizing potential.
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Authors | J Shibata, K Murakami, K Wierzba, Y Aoyagi, A Hashimoto, M Sano, T Toko, Y Yamada |
Journal | Anticancer research
(Anticancer Res)
2000 Sep-Oct
Vol. 20
Issue 5A
Pg. 3169-76
ISSN: 0250-7005 [Print] Greece |
PMID | 11062739
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Benzoates
- TAC 101
- Trimethylsilyl Compounds
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacokinetics, therapeutic use)
- Benzoates
(chemistry, pharmacokinetics, therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, secondary)
- Humans
- Liver Neoplasms
(drug therapy, secondary)
- Lung Neoplasms
(drug therapy)
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mice, SCID
- Molecular Structure
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Transplantation
- Trimethylsilyl Compounds
(chemistry, pharmacokinetics, therapeutic use)
- Tumor Cells, Cultured
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