Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma.

Abstract

The plasminogen activation system plays an important role in enhancing pericellular proteolysis of tumor invasion/metastasis and in autocrine/paracrine tumor growth stimulation. To investigate the prognostic significance of the plasminogen activation system in human chondrosarcoma, the immunohistochemical expression of urokinase-type plasminogen activator (uPA), urokinase-type plasminogen activator receptor (uPAR), plasminogen activator inhibitor, 1 (PAI-1) and 2 (PAI-2) were analyzed in 28 patients with chondrosarcoma. In multivariate survival analysis, histological grade (p = 0.0008) and location (p = 0.02) were independent risk factors for local relapse. For metastasis-free survival, uPA index (p = 0.006) and PAI-2 index (p = 0.04) were independent prognostic factors. PAI-2 index (p = 0.02), uPAR index (p = 0.02) and histological grade (p = 0.03) predicted total survival. These results demonstrated the usefulness of uPA, uPAR and PAI-2 expression as biological prognostic indicator and the importance of the plasminogen activation system in tumor progression and metastasis in chondrosarcoma.

• Authors: T Morii, H Yabe, H Morioka, R Yamada, T Nakagawa, Y Toyama
• Journal: Anticancer research (Anticancer Res) 2000 Sep-Oct Vol. 20 Issue 5A Pg. 3031-6 ISSN: 0250-7005 [Print] Greece
• PMID: 11062719 (Publication Type: Journal Article)

Chemical References

• PLAUR protein, human
• Plasminogen Activator Inhibitor 1
• Plasminogen Activator Inhibitor 2
• Receptors, Cell Surface
• Receptors, Urokinase Plasminogen Activator
• Urokinase-Type Plasminogen Activator

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Bone Neoplasms (classification, diagnosis, metabolism, pathology)
• Chondrosarcoma (classification, diagnosis, metabolism, pathology)
• Female
• Humans
• Immunohistochemistry (methods)
• Male
• Middle Aged
• Plasminogen Activator Inhibitor 1 (metabolism)
• Plasminogen Activator Inhibitor 2 (metabolism)
• Prognosis
• Receptors, Cell Surface (metabolism)
• Receptors, Urokinase Plasminogen Activator
• Urokinase-Type Plasminogen Activator (metabolism)