Meloxicam inhibits the growth of non-small cell lung cancer.

Abstract	Cyclooxygenase (COX)-2 has been reported to play an important role in carcinogenesis. Meloxicam (preferential COX-2 inhibitor) inhibits the growth of COX-2 positive and COX-1 negative colorectal cancer cells. We evaluated the effects of meloxicam on the growth of lung cancer cells. By reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis, COX-2 but not COX-1 was expressed in human non-small cell lung cancer (NSCLC) cell lines (A549 and PC14). In human small cell lung cancer (SCLC) cell line (H841), both COX-1 and COX-2 were not detected. MTT assay and prostaglandin (PG) E2 enzyme immunoassay showed that meloxicam inhibited the growth and PGE2 production of both A549 and PC14, but not H841 cells. These findings suggest that COX-2 may play an important role in the pathogenesis and progression of NSCLC, and that meloxicam may be a useful therapeutic agents in the treatment of NSCLC.
Authors	Y Tsubouchi, S Mukai, Y Kawahito, R Yamada, M Kohno, K Inoue, H Sano
Journal	Anticancer research (Anticancer Res) 2000 Sep-Oct Vol. 20 Issue 5A Pg. 2867-72 ISSN: 0250-7005 [Print] Greece
PMID	11062695 (Publication Type: Journal Article)
Chemical References	Antineoplastic Agents Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Growth Inhibitors Isoenzymes Membrane Proteins RNA, Messenger Thiazines Thiazoles Cyclooxygenase 1 Cyclooxygenase 2 PTGS1 protein, human PTGS2 protein, human Prostaglandin-Endoperoxide Synthases Dinoprostone Meloxicam
Topics	Antineoplastic Agents (pharmacology) Carcinoma, Non-Small-Cell Lung (drug therapy) Cell Division (drug effects) Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors (pharmacology) Dinoprostone (biosynthesis) Gene Expression Growth Inhibitors (pharmacology) Humans Isoenzymes (biosynthesis, genetics) Lung Neoplasms (drug therapy) Meloxicam Membrane Proteins Prostaglandin-Endoperoxide Synthases (biosynthesis, genetics) RNA, Messenger Thiazines (pharmacology) Thiazoles (pharmacology) Tumor Cells, Cultured

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