[Results of myocardial scintigraphy with 99mTc-tetrofosmin and dipyridamole administration in patients diagnosed of microvascular angina].

Abstract

The objective of the study was to evaluate the results of the myocardial scintigraphy with 99mTc-tetrofosmin (Tc-Tf) and pharmacological stimulation with dipyridamole in patients diagnosed of microvascular angina. The study population is made up of 50 patients discharged with the diagnosis of microvascular angina who had undergone Tc-Tf-dipyridamole. Clinical and electrical positivity appeared in 40% and 12% of the patients, respectively. Myocardial perfusion defects were found in 35 patients (70%), and were reversible in 21 (60%), fixed in 11 (21%), and combined in 3 (9%). Abnormalities were inferior, anteroseptal and lateral in 21, 18, and 2 patients, respectively. Patients with a positive exercise treadmill test, compared with those with a negative one, had more frequent perfusion abnormalities (91% vs 50%, p = 0.0327) and myocardial ischemia (64% vs 20%, p = 0.392). Women, in comparison with men, had angina (56% vs 22%, p = 0.013), and anteroseptal perfusion abnormalities (26% vs 4%, p = 0.028) more frequently. On the contrary, men had inferior perfusion abnormalities more frequently (57% vs 30%, p = 0.057). Thus, Tc-Tf-dipyridamole shows perfusion abnormalities in 70% of patients with microvascular angina (91% in patients with a positive exercise treadmill test). Scintigraphic pattern may be partially conditioned by gender in these patients.

• Authors: A Ortega, R Moreno, J C Alonso, P Domínguez, I Almoguera, A Bittini, J L Lampreave, M Suárez, A Gómez, L Martínez, V Sosa, F Sarnago, M A García-Fernández, J M Pérez-Vázquez
• Journal: Revista espanola de medicina nuclear (Rev Esp Med Nucl) Vol. 19 Issue 5 Pg. 337-73 (Sep 2000) ISSN: 0212-6982 [Print] Spain
• Vernacular Title: Resultados de la gammagrafía de perfusión miocárdica con 99mTc-tetrofosmina y estímulo con dipiridamol en pacientes diagnosticados de angina microvascular.
• PMID: 11062109 (Publication Type: Journal Article)

Chemical References

• Organophosphorus Compounds
• Organotechnetium Compounds
• Radiopharmaceuticals
• Vasodilator Agents
• technetium tc-99m tetrofosmin
• Dipyridamole

Topics

• Coronary Circulation
• Dipyridamole
• Female
• Heart (diagnostic imaging)
• Humans
• Male
• Microvascular Angina (diagnostic imaging)
• Middle Aged
• Organophosphorus Compounds
• Organotechnetium Compounds
• Radionuclide Imaging
• Radiopharmaceuticals
• Retrospective Studies
• Vasodilator Agents