[Clinical study on a new acetylsalicylic acid/paracetamol preparation with gastric acid resistant coating (Safapryn), and on two various phenylbutazone dosages in patients with primary chronic polyarthritis as based on a new evaluation method].

Abstract

The authors describe a simple non-crossover-blind test for the evaluation of subjective indices. A table for recording pains during the 14 days' study is described. The patient's satisfaction with the treatment and the number of days until withdrawal from the trial are recorded. The statistical procedure takes into consideration differences between the treatment groups and makes possible a valuable comparison with drugs tested in other clinical trials. The three dose schedules of antirheumatic treatment were tested on 122 patients and the results compared with those of 342 patients treated with the 6 other antirheumatic drugs (enteric-coated aspirin, paracetamol, indomethacin, flurbiprofen, mefenamic acid, and prednisolone) and those of 41 patients who received placebos. The results show that Safapryn (3,6 g aspirin + 3.0 g paracetamol daily) compared with 3.9 g enteric coated aspirin does not offer any advantage in its analgesic effect, although it gives rise to fewer side effects. Phenylbutazone (3000 mg) was almost as effective as 15 mg prednisolone daily. Between the effects of this dosage of phenylbutazone and other non-steroidal antirheumatic drugs, however, no significant difference could be detected. 50 mg phenylbutazone daily and placebo treatment could not be distinguished. The authors thank the Arthritis and Rheumatism Council for Research in Great Britain for its financial support. One of the authors (PL) was a Merck, Sharp, and Dohme Research Fellow and another one (PMB) received a Robins research scholarship.

• Authors: P M Brooks, J J Walker, P Lee, A M Bell, W W Buchanan, P D Fowler, J A Anderson
• Journal: Zeitschrift fur Rheumatologie (Z Rheumatol) 1975 Sep-Oct Vol. 34 Issue 9-10 Pg. 350-65 ISSN: 0340-1855 [Print] Germany
• Vernacular Title: Erprobung eines neuen Acetylsalicylsäure/Paracetamol-Präparates mit magensaftresistentem Uberzug (Safapryn) und zwei verschiedenen Dosierungen von Phenylbutazon bei Patienten mit primär chronischer Polyarthritis anhand eines neuen Bewertungsverfahrens
• PMID: 1106038 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Placebos
• Tablets, Enteric-Coated
• Acetaminophen
• Phenylbutazone
• Aspirin

Topics

• Acetaminophen (administration & dosage, adverse effects, therapeutic use)
• Arthritis, Rheumatoid (drug therapy)
• Aspirin (administration & dosage, adverse effects, therapeutic use)
• Clinical Trials as Topic
• Drug Administration Schedule
• Drug Combinations
• Drug Evaluation (methods)
• Humans
• Middle Aged
• Phenylbutazone (administration & dosage, adverse effects, therapeutic use)
• Placebos
• Tablets, Enteric-Coated