Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris.

Abstract

A new enzyme-linked immunosorbent assay can detect 10 pg/ml of human hepatocyte growth factor (HGF). Circulating HGF was significantly higher in patients with unstable angina (296+/-184 pg/ml, mean+/-SD, n=36) than in healthy volunteers (201+/-64 pg/ml, n=250, p<0.0001). Individual concentrations exceeded the mean control value +2 SD (329 pg/ml) in 12 of the 36 (33%) patients with unstable angina. The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina.

• Authors: A Matsumori, S Miyazaki, H Takano, K Ono, M Okada, T Miyamoto, H Nonogi, S Daikoku, K Mitsudo, Y Matsunaga, T Ohnishi, Y Daikuhara, S Sasayama
• Journal: Japanese circulation journal (Jpn Circ J) Vol. 64 Issue 10 Pg. 805-7 (Oct 2000) ISSN: 0047-1828 [Print] Japan
• PMID: 11059627 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Troponin T
• Hepatocyte Growth Factor
• Creatine Kinase

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Angina, Unstable (blood, diagnosis)
• Biomarkers (blood)
• Coronary Thrombosis (blood, diagnosis)
• Creatine Kinase (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Hepatocyte Growth Factor (blood)
• Humans
• Male
• Middle Aged
• Troponin T (blood)