Anti-analgesic and anti-amnesic effect of complement C3a.

In the present study, we found that complement C3a exerted central effects after intracerebroventricular administration in mice. At doses of 3 and 10 pmol/mouse, the peptide showed an antagonistic effect on analgesia induced by morphine and U-50488H, known to be mu- and kappa-opioid receptor agonists, respectively. Moreover, complement C3a improved scopolamine- and ischemia-induced amnesia at a dose of 10 pmol/mouse. Anti-analgesia was not observed by C3a des-Arg at 10 pmol/mouse. The present findings suggest that complement C3a may act as a peptide with anti-opioid activity in the central nervous system.
AuthorsY Jinsmaa, M Takahashi, M Takahashi, M Yoshikawa
JournalLife sciences (Life Sci) Vol. 67 Issue 17 Pg. 2137-43 (Sep 15 2000) ISSN: 0024-3205 [Print] ENGLAND
PMID11057763 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Oligopeptides
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu
  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
  • Morphine
  • Complement C3a
  • deltakephalin
  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer (administration & dosage, antagonists & inhibitors, pharmacology)
  • Analgesics (administration & dosage, pharmacology)
  • Animals
  • Avoidance Learning (drug effects)
  • Cerebral Ventricles (drug effects, physiology)
  • Complement C3a (administration & dosage, pharmacology)
  • Dose-Response Relationship, Drug
  • Electroshock
  • Humans
  • Injections, Intraventricular
  • Ischemia (physiopathology)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Morphine (administration & dosage, antagonists & inhibitors, pharmacology)
  • Oligopeptides (administration & dosage, pharmacology)
  • Pain (physiopathology)
  • Receptors, Opioid, delta (agonists)
  • Receptors, Opioid, kappa (agonists)
  • Receptors, Opioid, mu (agonists)

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