An efficacy and tolerance comparison of emedastine difumarate 0.05% and levocabastine hydrochloride 0.05%: reducing chemosis and eyelid swelling in subjects with seasonal allergic conjunctivitis. Emadine Study Group.

Abstract

PURPOSE:

To compare emedastine ophthalmic solution 0.05% BID to levocabastine ophthalmic suspension 0.05% BID in reducing chemosis, eyelid swelling and other signs and symptoms in subjects with seasonal allergic conjunctivitis.

METHODS:

In a randomized, double-masked, parallel controlled study, emedastine ophthalmic solution 0.05% BID was compared to levocabastine ophthalmic suspension 0.05% BID for control of chemosis, eyelid swelling and other parameters in the environmental allergy study model.

RESULTS:

At Days 7, 14, 30 and 42, emedastine was significantly better than levocabastine at controlling chemosis and eyelid swelling (p < 0.05). A statistical trend was seen at Day 3 (0.05 < p < 0.10). Results were clinically relevant at Days 30 and 42. Emedastine was also significantly better at reducing redness and itching at Days 7, 14, 30 and 42 (p < 0.05).

CONCLUSION:

Emedastine is more efficacious than levocabastine in reducing chemosis, eyelid swelling and other efficacy variables associated with seasonal allergic conjunctivitis.

• Authors: A Secchi, A Leonardi, M Discepola, J Deschenes, M B Abelson
• Journal: Acta ophthalmologica Scandinavica. Supplement (Acta Ophthalmol Scand Suppl) Issue 230 Pg. 48-51 ( 2000) ISSN: 1395-3931 [Print] Denmark
• PMID: 11057351 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Benzimidazoles
• Histamine H1 Antagonists
• Ophthalmic Solutions
• Piperidines
• emedastine
• levocabastine

Topics

• Adolescent
• Adult
• Aged
• Benzimidazoles (administration & dosage, adverse effects, therapeutic use)
• Child
• Child, Preschool
• Conjunctiva (drug effects)
• Conjunctivitis, Allergic (drug therapy, pathology)
• Double-Blind Method
• Edema (drug therapy, pathology)
• Eyelid Diseases (drug therapy, pathology)
• Female
• Histamine H1 Antagonists (administration & dosage, adverse effects, therapeutic use)
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions
• Piperidines (administration & dosage, adverse effects, therapeutic use)
• Safety
• Seasons
• Treatment Outcome