Abstract | UNLABELLED: In this prospective, randomized, placebo-controlled study, we (1) determined whether 0.625 mg of IV droperidol given 30 min before emergence from general anesthesia reduces the incidence of immediate and delayed postoperative nausea and vomiting ( PONV) in a general surgical adult patient population, and (2) compared the efficacy of droperidol, ondansetron, and promethazine for the rescue treatment of PONV. One hundred fifty adult patients receiving general anesthesia for >2 h received either droperidol (0.625 mg IV) or a placebo before emergence. Patients requiring treatment for PONV in the postanesthesia care unit were randomized to receive either droperidol (0.625 mg IV), ondansetron (4 mg IV), or promethazine (12. 5 mg IV). Droperidol effectively prevented PONV (6.8% in droperidol-treated patients versus 40.8% in placebo-treated patients, P: < 0.001). Droperidol, ondansetron, and promethazine were equally effective in treating established PONV, without significant differences in side effects or time to postanesthesia care unit discharge. IMPLICATIONS:
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Authors | N S Kreisler, B F Spiekermann, C M Ascari, H A Rhyne, R L Kloth, L M Sullivan, M E Durieux |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 91
Issue 5
Pg. 1256-61
(Nov 2000)
ISSN: 0003-2999 [Print] United States |
PMID | 11049918
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antiemetics
- Ondansetron
- Promethazine
- Droperidol
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Topics |
- Anesthesia, General
- Antiemetics
(administration & dosage, adverse effects)
- Double-Blind Method
- Droperidol
(administration & dosage, adverse effects)
- Female
- Humans
- Male
- Middle Aged
- Ondansetron
(therapeutic use)
- Postoperative Nausea and Vomiting
(drug therapy, prevention & control)
- Promethazine
(therapeutic use)
- Prospective Studies
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