A technique for intensifying BCG sensitivity.

Abstract

Sensitization to BCG (Bacille Calmette-Guérin) appears to be more effective when it is carried out at the site of a delayed hypersensitivity challenge reaction to DNCB (1-chloro, 2,4-dinitrobenzene) than when it is carried out at unchallenged sites in non-sensitized animals. The effectiveness of BCG sensitization was determined by measurement of the intensity of the PPD (Purified Protein Derivative of tuberculin) 24-hour skin test. Possible mechanisms for this phenomenon and its implications for cancer immunotherapy are considered.

• Authors: S R Parmett, E Klein
• Journal: Journal of medicine (J Med) Vol. 6 Issue 3-4 Pg. 213-6 ( 1975) ISSN: 0025-7850 [Print] United States
• PMID: 1104733 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• BCG Vaccine
• Dinitrochlorobenzene
• Nitrobenzenes

Topics

• Animals
• BCG Vaccine
• Dinitrochlorobenzene (immunology)
• Guinea Pigs
• Hypersensitivity, Delayed
• Immunity, Cellular
• Immunotherapy
• Mycobacterium bovis (immunology)
• Neoplasms (immunology, therapy)
• Nitrobenzenes (immunology)
• Tuberculin Test