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Treatment of Peyronie's disease with oral colchicine: long-term results and predictive parameters of successful outcome.

Abstract
As recent clinical and animal studies have indicated, colchicine, with its anti-fibrotic, anti-mitotic and anti-inflammatory activities, has suppressive effects in the pathogenesis of Peyronie's disease. Oral colchicine treatment was initiated in 60 Peyronie's patients during their acute phase (mean duration of disease: 5.7 +/- 4.3 months). Long-term results, based on changes of subjective and objective criteria, were assessed and predictive factors of successful outcome were investigated. After a mean follow-up of 10.7 +/- 4.7 months, the penile deformity improved in 30%, remained unchanged in 48.3% and deteriorated in 21.7%. Pain resolved in 95%. Best results were obtained in those with no risk factor for vascular disease, presenting during the initial 6 months of disease, degree of curvature <30 degrees, no erectile dysfunction by history and positive response to combined injection and stimulation test. In conclusion since tunica albuginea is affected as a whole in Peyronie's disease, systemic oral agents, such as colchicine, may be preferred in the early phase of the disease.
AuthorsA Kadioglu, A Tefekli, T Köksal, M Usta, H Erol
JournalInternational journal of impotence research (Int J Impot Res) Vol. 12 Issue 3 Pg. 169-75 (Jun 2000) ISSN: 0955-9930 [Print] England
PMID11045911 (Publication Type: Journal Article)
Chemical References
  • Colchicine
Topics
  • Adult
  • Aged
  • Colchicine (adverse effects, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Pain
  • Penile Erection
  • Penile Induration (drug therapy, pathology)
  • Penis (abnormalities)
  • Treatment Outcome

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