HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

UVAI-induced edema and pyrimidine dimers in murine skin.

Abstract
The induction of edema and pyrimidine dimers in epidermal DNA was determined in the skin of SKH:HR1 mice exposed to graded doses of ultraviolet radiation AI (UVAI; 340-400 nm). Exposure to UVAI induced 1.6 +/- 0.08 x 10(-6) (mean +/- standard error of mean) pyrimidine dimers per 10(8) Da of DNA per J/m2. Edema in irradiated animals was determined as an increase in skinfold thickness. A dose of 1.8 x 10(6) J/m2 of UVAI that resulted in a 50% increase in skinfold thickness (SFT50%) would have induced 1.0 x 10(5) dimers per basal cell genome. A similar increase in SFT induced by full spectrum solar ultraviolet radiation (290-400 nm) would accompany the induction of 11.0 x 10(5) pyrimidine dimers per basal cell genome. These results support a hypothesis that UVAI-induced pathological changes of the skin are mediated through the formation of nondimer photoproducts.
AuthorsR D Ley, A Fourtanier
JournalPhotochemistry and photobiology (Photochem Photobiol) Vol. 72 Issue 4 Pg. 485-7 (Oct 2000) ISSN: 0031-8655 [Print] United States
PMID11045719 (Publication Type: Journal Article)
Chemical References
  • Pyrimidine Dimers
  • DNA
Topics
  • Animals
  • DNA (metabolism, radiation effects)
  • DNA Damage
  • Edema (etiology, metabolism)
  • Female
  • Mice
  • Mice, Hairless
  • Pyrimidine Dimers (biosynthesis, radiation effects)
  • Radiation Injuries, Experimental (etiology, metabolism)
  • Skin (metabolism, radiation effects)
  • Skin Diseases (etiology, metabolism)
  • Ultraviolet Rays (adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: