Abstract |
The induction of edema and pyrimidine dimers in epidermal DNA was determined in the skin of SKH:HR1 mice exposed to graded doses of ultraviolet radiation AI (UVAI; 340-400 nm). Exposure to UVAI induced 1.6 +/- 0.08 x 10(-6) (mean +/- standard error of mean) pyrimidine dimers per 10(8) Da of DNA per J/m2. Edema in irradiated animals was determined as an increase in skinfold thickness. A dose of 1.8 x 10(6) J/m2 of UVAI that resulted in a 50% increase in skinfold thickness (SFT50%) would have induced 1.0 x 10(5) dimers per basal cell genome. A similar increase in SFT induced by full spectrum solar ultraviolet radiation (290-400 nm) would accompany the induction of 11.0 x 10(5) pyrimidine dimers per basal cell genome. These results support a hypothesis that UVAI-induced pathological changes of the skin are mediated through the formation of nondimer photoproducts.
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Authors | R D Ley, A Fourtanier |
Journal | Photochemistry and photobiology
(Photochem Photobiol)
Vol. 72
Issue 4
Pg. 485-7
(Oct 2000)
ISSN: 0031-8655 [Print] United States |
PMID | 11045719
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- DNA
(metabolism, radiation effects)
- DNA Damage
- Edema
(etiology, metabolism)
- Female
- Mice
- Mice, Hairless
- Pyrimidine Dimers
(biosynthesis, radiation effects)
- Radiation Injuries, Experimental
(etiology, metabolism)
- Skin
(metabolism, radiation effects)
- Skin Diseases
(etiology, metabolism)
- Ultraviolet Rays
(adverse effects)
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