Abstract |
To explore the pathogenesis of benign familial neonatal convulsions (BFNC), we determined effects of KCNQ-related M-channels (KCNQ-channels) on hippocampal glutamate (Glu) and gamma-aminobutyric acid ( GABA) releases using microdialysis, and propagation of evoked field-potentials (FP) using multielectrode (64-ch)-dish system as two-dimensional monitoring. KCNQ-channel inhibitor, Dup996, enhanced hippocampal K(+)-evoked Glu and GABA releases without affecting basal releases of them. Dup996 unaffected FP-amplitude, but enhanced FP-propagation. The GABA(A)-receptor antagonist, bicuculline, enhanced the stimulatory effects of Dup996 on FP-propagation, however, this stimulatory effects of Dup996 were abolished by the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ( AMPA)/ glutamate-receptor antagonist, DNQX. These results suggest that the occurrence of BFNC cannot be produced by KCNQ-channel dysfunction alone, but by reciprocal action between impaired KCNQ-channel and other unknown elements (possibly dysfunction of inhibitory neurotransmission system).
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Authors | G Zhu, M Okada, T Murakami, A Kamata, Y Kawata, K Wada, S Kaneko |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 294
Issue 1
Pg. 53-7
(Nov 10 2000)
ISSN: 0304-3940 [Print] Ireland |
PMID | 11044585
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Excitatory Amino Acid Antagonists
- GABA Antagonists
- Indoles
- KCNQ Potassium Channels
- KCNQ2 Potassium Channel
- KCNQ3 Potassium Channel
- Kcnq2 protein, rat
- Kcnq3 protein, rat
- Kcnq5 protein, rat
- Potassium Channels
- Potassium Channels, Voltage-Gated
- Pyridines
- Quinoxalines
- Glutamic Acid
- gamma-Aminobutyric Acid
- FG 9041
- linopirdine
- Potassium
- Bicuculline
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Topics |
- Action Potentials
(drug effects)
- Animals
- Bicuculline
(pharmacology)
- Electrodes
- Epilepsy, Benign Neonatal
(etiology, metabolism)
- Excitatory Amino Acid Antagonists
(pharmacology)
- Excitatory Postsynaptic Potentials
(drug effects)
- GABA Antagonists
(pharmacology)
- Glutamic Acid
(metabolism)
- Hippocampus
(cytology, drug effects, metabolism)
- In Vitro Techniques
- Indoles
(pharmacology)
- KCNQ Potassium Channels
- KCNQ2 Potassium Channel
- KCNQ3 Potassium Channel
- Male
- Microdialysis
(methods)
- Neurons
(cytology, drug effects, metabolism)
- Potassium
(metabolism, pharmacology)
- Potassium Channels
(metabolism)
- Potassium Channels, Voltage-Gated
- Pyridines
(pharmacology)
- Quinoxalines
(pharmacology)
- Rats
- Rats, Wistar
- gamma-Aminobutyric Acid
(metabolism)
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