Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer.

Abstract

This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with colorectal cancer (cases). Comparisons were made with 57 individuals who had a normal colonoscopy (controls). Serial changes were examined in 27 cases. As IGF-related peptides are age- and sex-dependent, absolute concentrations were converted to standard deviation scores (SDS). Mean IGF-II SDS were elevated in Dukes A (n = 12, P< 0.001) and Dukes B (n = 25, P< 0.001) cases compared with controls, but not in advanced disease. Compared with controls, mean IGFBP-2 SDS were significantly elevated in patients with Dukes B (P< 0.001), Dukes C (n = 13, P< 0.001) and advanced disease (n = 42, P< 0.0001), with a significant trend from early to advanced disease (one-way ANOVA, P< 0.001). Furthermore, IGFBP-2 SDS were positively related to tumour size (P = 0.01) and fell significantly in patients following curative resection (P = 0.04), suggesting that circulating levels reflect tumour load. We tested the potential tumour marker characteristics of IGFBP-2 SDS against three endpoints: metastasis alone; local pelvic recurrence alone; and metastasis and recurrence combined. The sensitivities for IGFBP-2 alone (>/= + 2SD) were modest at 55%, 46%, and 52%, but in combination with CEA, increased substantially to 90%, 77% and 86%, respectively. We conclude that the serum IGF-II and IGFBP-2 profiles may provide insights into underlying biological mechanisms, and that serum IGFBP-2 may have an adjunct role in cancer surveillance in patients with colorectal cancer.

• Authors: A G Renehan, J Jones, C S Potten, S M Shalet, S T O'Dwyer
• Journal: British journal of cancer (Br J Cancer) Vol. 83 Issue 10 Pg. 1344-50 (Nov 2000) ISSN: 0007-0920 [Print] England
• PMID: 11044360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2000 Cancer Research Campaign.

Chemical References

• Biomarkers, Tumor
• Insulin-Like Growth Factor Binding Protein 2
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor I
• Insulin-Like Growth Factor II

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis)
• Colorectal Neoplasms (pathology)
• Female
• Humans
• Insulin-Like Growth Factor Binding Protein 2 (analysis)
• Insulin-Like Growth Factor Binding Protein 3 (analysis)
• Insulin-Like Growth Factor I (analysis)
• Insulin-Like Growth Factor II (analysis)
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Sensitivity and Specificity