Abstract |
We report a 5-year-old boy with juvenile myelomonocytic leukemia (JMML) which relapsed after an allogeneic bone marrow transplant who was successfully treated with interferon-alpha (IFN-alpha). One year after starting the therapy, he remains clinically well and in complete remission while continuing treatment with IFN-alpha and bestatin. Although the precise mechanism by which remission was induced is uncertain, a GVL effect combined with a direct antileukemia effect of IFN-alpha may be responsible. Further assessment of the role of IFN-alpha in relapsed JMLL patients is warranted.
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Authors | H Ohta, M Kawai, A Sawada, S Tokimasa, H Fujisaki, Y Matsuda, Y Osugi, S Okada, J Hara |
Journal | Bone marrow transplantation
(Bone Marrow Transplant)
Vol. 26
Issue 6
Pg. 681-3
(Sep 2000)
ISSN: 0268-3369 [Print] England |
PMID | 11041570
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Interferon-alpha
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Bone Marrow Transplantation
- Child, Preschool
- Combined Modality Therapy
- Graft vs Leukemia Effect
- Humans
- Interferon-alpha
(therapeutic use)
- Leukemia, Myelomonocytic, Chronic
(drug therapy, therapy)
- Male
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