Abstract | OBJECTIVE: DESIGN: Meta-analysis. IDENTIFICATION: Systematic search of the Medline database from January 1994 to June 1999 for English language studies examining drug treatment for lipid disorders (use of the MeSH terms " hyperlipidemia" and " anticholesteremic agents," keyword searches for individual drug names, and a search strategy for identifying randomised trials to capture relevant articles); identification of older studies through systematic reviews and hand search of bibliographies. INCLUSION CRITERIA: DATA EXTRACTION: Review of the articles and extracted relevant data by two authors separately, with disagreements resolved by consensus. RESULTS: Four studies met eligibility criteria. Drug treatment reduced the odds of a coronary heart disease event by 30% (summary odds ratio 0.70, 95% confidence interval 0.62 to 0.79) but not the odds of all cause mortality (0.94, 0.81 to 1.09). When statin drugs were considered alone, no substantial differences in results were found. CONCLUSIONS:
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Authors | M Pignone, C Phillips, C Mulrow |
Journal | BMJ (Clinical research ed.)
(BMJ)
Vol. 321
Issue 7267
Pg. 983-6
(Oct 21 2000)
ISSN: 0959-8138 [Print] England |
PMID | 11039962
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Cause of Death
- Coronary Disease
(mortality, prevention & control)
- Female
- Humans
- Hypolipidemic Agents
(therapeutic use)
- Male
- Middle Aged
- Myocardial Infarction
(prevention & control)
- Odds Ratio
- Primary Health Care
(methods)
- Randomized Controlled Trials as Topic
- Risk
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