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The effects of glurenorm on plasma glucose and lipids in patients with type 2 diabetes mellitus.

AbstractBACKGROUND:
The effects of sulfonylureas on plasma glucose, lipids, and macrovascular complications are of interest. This study was designed to investigate the effects of glurenorm on plasma glucose and lipids in patients with type 2 diabetes mellitus.
METHODS:
Nineteen patients, 15 men and 4 women, with an age range of 38-69 years, and with type 2 diabetes mellitus, were studied. Plasma glucose, glycated hemoglobin, and lipids were compared before and 3 months after glurenorm treatment.
RESULTS:
Fasting and postprandial plasma glucose, and HbA1c significantly improved after 3 months of glurenorm treatment. The mean (+/- SD) triglyceride level of 10 patients with mild to moderate hypertriglyceridemia decreased from 279 +/- 66 to 219 +/- 100 mg/dl (p = 0.054). The total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) of 14 hypercholesterolemic patients did not change significantly. Their mean body weight increased significantly from 65.7 +/- 9.6 to 67.2 +/- 9.9 kg (p = 0.002).
CONCLUSION:
Glurenorm was effective for glycemic control but caused weight gain in type 2 diabetic patients. Triglycerides in hypertriglyceridemic patients, and total cholesterol, LDL-C, and HDL-C in hypercholesterolemic patients did not improve after glurenorm treatment.
AuthorsS C Chou, K W Chen, C C Huang, K D Lin, J S Hwang, J D Lin
JournalChang Gung medical journal (Chang Gung Med J) Vol. 23 Issue 8 Pg. 480-4 (Aug 2000) ISSN: 2072-0939 [Print] China (Republic : 1949- )
PMID11039250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Cholesterol, HDL
  • Hypoglycemic Agents
  • Lipids
  • Sulfonylurea Compounds
  • gliquidone
Topics
  • Adult
  • Aged
  • Blood Glucose (analysis)
  • Cholesterol, HDL (blood)
  • Diabetes Mellitus, Type 2 (blood, drug therapy)
  • Female
  • Humans
  • Hypoglycemic Agents (therapeutic use)
  • Lipids (blood)
  • Male
  • Middle Aged
  • Sulfonylurea Compounds (therapeutic use)
  • Weight Gain (drug effects)

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