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Methemoglobinemia after infusion of ifosfamide chemotherapy: first report of a potentially serious adverse reaction related to ifosfamide.

Abstract
Acute formation of methemoglobin is a life-threatening condition caused by multiple medications. In this article we report the first case of methemoglobinemia in a patient with metastatic uterine leiomyosarcoma, after infusion of ifosfamide chemotherapy. The patient recovered after prompt diagnosis and treatment of the condition. A mechanism for the formation of methemoglobin as a result of the ifosfamide infusion is offered.
AuthorsD Hadjiliadis, J A Govert
JournalChest (Chest) Vol. 118 Issue 4 Pg. 1208-10 (Oct 2000) ISSN: 0012-3692 [Print] United States
PMID11035699 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents, Alkylating
  • Biomarkers
  • Methemoglobin
  • Ifosfamide
Topics
  • Antineoplastic Agents, Alkylating (administration & dosage, adverse effects)
  • Biomarkers (blood)
  • Diagnosis, Differential
  • Female
  • Humans
  • Ifosfamide (administration & dosage, adverse effects)
  • Infusions, Intravenous
  • Leiomyosarcoma (drug therapy)
  • Methemoglobin (metabolism)
  • Methemoglobinemia (blood, chemically induced, diagnosis)
  • Middle Aged
  • Uterine Neoplasms (drug therapy)

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