Successful zonisamide treatment for infants with hypsarrhythmia.

Abstract

We determined that zonisamide was effective in three epileptic infants with hypsarrhythmia. Two patients had the electroencephalographic pattern of hypsarrhythmia associated with developmental delay but lacked the characteristic tonic spasms. A third patient exhibited the typical triad of infantile spasms but had a poor general condition requiring controlled ventilation. We therefore chose zonisamide instead of adrenocorticotropin for these patients. Our data suggest that zonisamide may be a useful treatment in patients falling short of the diagnostic triad of infantile spasms or complicated by a poor overall medical condition.

• Authors: T Kishi, Y Nejihashi, M Kajiyama, K Ueda
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 23 Issue 3 Pg. 274-7 (Sep 2000) ISSN: 0887-8994 [Print] United States
• PMID: 11033295 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Isoxazoles
• Zonisamide

Topics

• Anticonvulsants (administration & dosage, adverse effects)
• Cerebral Cortex (drug effects)
• Electroencephalography (drug effects)
• Female
• Humans
• Infant
• Isoxazoles (administration & dosage, adverse effects)
• Male
• Spasms, Infantile (drug therapy)
• Zonisamide