Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix.

Pyoderma gangrenosum sometimes takes a recalcitrant course that is unresponsive to standard immuno-suppression with corticosteroids and/or cyclosporin A. In these cases improvement of painful ulcerations is a therapeutic challenge. We report a 17-year-old boy with severe pyoderma gangrenosum treated successfully with mycophenolate mofetil and autologous keratinocyte transplantation using an esterified hyluronic acid delivery system.
AuthorsU Wollina, T Karamfilov
JournalJournal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 14 Issue 3 Pg. 187-90 (May 2000) ISSN: 0926-9959 [Print] NETHERLANDS
PMID11032062 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Hyaluronic Acid
  • mycophenolate mofetil
  • Mycophenolic Acid
  • Adolescent
  • Humans
  • Hyaluronic Acid (administration & dosage)
  • Immunosuppressive Agents (therapeutic use)
  • Keratinocytes (transplantation)
  • Male
  • Mycophenolic Acid (analogs & derivatives, therapeutic use)
  • Pyoderma Gangrenosum (therapy)
  • Transplantation, Autologous

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