Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission.

Abstract

Rab GDP dissociation inhibitor alpha (Rab GDIalpha) is a regulator of the Rab small G proteins implicated in neurotransmission, and mutations of Rab GDIalpha cause human X-linked mental retardation associated with epileptic seizures. In Rab GDIalpha-deficient mice, synaptic potentials in the CA1 region of the hippocampus displayed larger enhancement during repetitive stimulation, which was apparently opposite to the phenotype of Rab3A-deficient mice. Furthermore, the Rab GDIalpha-deficient mice showed hypersensitivity to bicuculline, an inducer of epileptic seizures. These results suggest that Rab GDIalpha plays a specialized role in Rab3A recycling to suppress hyperexcitability via modulation of presynaptic forms of plasticity.

• Authors: H Ishizaki, J Miyoshi, H Kamiya, A Togawa, M Tanaka, T Sasaki, K Endo, A Mizoguchi, S Ozawa, Y Takai
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 97 Issue 21 Pg. 11587-92 (Oct 10 2000) ISSN: 0027-8424 [Print] United States
• PMID: 11027356 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Primers
• Excitatory Amino Acid Antagonists
• GABA Antagonists
• GDP dissociation inhibitor 1
• Guanine Nucleotide Dissociation Inhibitors
• N-Methylaspartate
• Dizocilpine Maleate
• rab3 GTP-Binding Proteins

Topics

• Animals
• Base Sequence
• DNA Primers
• Dizocilpine Maleate (pharmacology)
• Excitatory Amino Acid Antagonists (pharmacology)
• GABA Antagonists (pharmacology)
• Guanine Nucleotide Dissociation Inhibitors (physiology)
• Hippocampus (physiology)
• Humans
• In Vitro Techniques
• Mice
• Mice, Inbred C57BL
• N-Methylaspartate (physiology)
• Neuronal Plasticity (physiology)
• Seizures (chemically induced)
• Subcellular Fractions (metabolism)
• Synaptic Transmission (physiology)
• rab3 GTP-Binding Proteins (metabolism)