Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Of the 28 male and 6 female infants who met study criteria vesicoureteral reflux was bilateral in 25 and unilateral in 9. Reflux grade was IV or V, II or III and I in 38, 18 and 3 of the 59 refluxing renal units, respectively. 99mTc-DMSA renal scintigraphy revealed parenchymal abnormalities in 24 refluxing renal units (41%) in 22 patients (65%), of whom 19 (86%) were male and 15 (68%) had bilateral reflux. We noted differential uptake less than 40% with and without cortical defects in 10 and 7 refluxing units, respectively, and cortical defects only in 7. Of the 24 refluxing units with abnormalities 21 were associated with grade IV or V and 3 with grade II or III reflux. Ultrasound showed evidence of renal injury in only 7 of the 17 patients (41%) in whom 99mTc-DMSA scintigraphy was abnormal. CONCLUSIONS: In our study the majority of infants with high grade reflux had decreased differential function and/or cortical defects. Parenchymal defects detected by 99mTc-DMSA renal scintigraphy were often not identified by renal ultrasound. Therefore, 99mTc-DMSA renal scintigraphy is especially useful for initially evaluating infants with high grade, sterile vesicoureteral reflux.
|
Authors | H T Nguyen, S B Bauer, C A Peters, L P Connolly, R Gobet, J G Borer, C E Barnewolt, P L Ephraim, S T Treves, A B Retik |
Journal | The Journal of urology
(J Urol)
Vol. 164
Issue 5
Pg. 1674-8; discussion 1678-9
(Nov 2000)
ISSN: 0022-5347 [Print] United States |
PMID | 11025746
(Publication Type: Journal Article)
|
Chemical References |
- Radiopharmaceuticals
- Technetium Tc 99m Dimercaptosuccinic Acid
|
Topics |
- Female
- Humans
- Infant, Newborn
- Kidney
(diagnostic imaging, physiopathology)
- Male
- Radionuclide Imaging
- Radiopharmaceuticals
- Retrospective Studies
- Technetium Tc 99m Dimercaptosuccinic Acid
- Urodynamics
- Vesico-Ureteral Reflux
(diagnostic imaging)
|