[Immunoguided surgery].

Abstract

Radioimmunoguided surgery has been attempted using intraoperative tumor detection with radiolabeled monoclonal antibody (mAb). Directly radiolabeled mAb showed poor tumor imaging due to high blood-pool radioactivity. In 1991, three-step immunoscintigraphy of the avidin-biotin system was reported. This three-step method improved tumor imaging because it reduced background radioactivity. Although there were some problems such as a human anti-mouse response and anti-avidin response, the three-step clinical protocol was performed in various cancer patients, and many good results (the tumor detection rate was about 85%) were reported. On the other hand, recent major trials on tumor localization and sentinel lymph node detection have been performed using FDG-PET. However, radioimmunoscintigraphy has the major advantage of simultaneous tumor diagnosis and treatment. In the near future, radioimmunoscintigraphy may become a useful diagnostic method with anticancer effects when its adverse effects are ameliorated by the application of gene technology.

• Authors: H Yamana
• Journal: Nihon Geka Gakkai zasshi (Nihon Geka Gakkai Zasshi) Vol. 101 Issue 9 Pg. 602-6 (Sep 2000) ISSN: 0301-4894 [Print] Japan
• PMID: 11022674 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antibodies, Monoclonal
• Radioisotopes

Topics

• Antibodies, Monoclonal
• Carcinoma, Squamous Cell (immunology, surgery)
• Esophageal Neoplasms (immunology, surgery)
• Humans
• Lymph Nodes (immunology)
• Neoplasms (immunology, surgery)
• Radioimmunodetection (methods)
• Radioisotopes