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[Fludarabine treatment of chronic lymphoid leukemia].

AbstractAIM:
To try effectiveness of fludarabine monotherapy in verified chronic lymphoid leukemia (CLL) in pretreated patients.
MATERIAL AND METHODS:
The treatment effectiveness according to the international criteria of complete and partial remission was assessed in 37 patients with progressive, splenic, tumor and bone marrow forms of CLL given 5-day courses of fludarabine in a single daily dose 25 mg.
RESULTS:
In progressive CLL, the remission was achieved in 45% of the patients (10% complete and 35% partial), in splenic form--62.5% (12.5% complete, 50% partial), in tumor form--50% (100% partial). In bone marrow form no remissions were obtained.
CONCLUSION:
Fludarabine is effective in therapy of pretreated CLL patients. The treatment should be adjusted to CLL form.
AuthorsN G Gabeeva, A V Pivnik, T N Moiseeva, E E Zybunova, R S Samoĭlova, A M Kremenetskaia, E Iu Varlamova, I B Kaplanskaia
JournalTerapevticheskii arkhiv (Ter Arkh) Vol. 72 Issue 8 Pg. 42-5 ( 2000) ISSN: 0040-3660 [Print] Russia (Federation)
Vernacular TitleFliudarabin v lechenii khronicheskogo limfoleĭkoza.
PMID11019427 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Vidarabine
  • fludarabine
Topics
  • Adult
  • Antineoplastic Agents (administration & dosage)
  • Bone Marrow (pathology)
  • Disease Progression
  • Female
  • Humans
  • Injections, Intravenous
  • Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy, pathology)
  • Male
  • Middle Aged
  • Remission Induction
  • Retrospective Studies
  • Vidarabine (administration & dosage, analogs & derivatives)

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