Abstract | BACKGROUND: METHODS: RESULTS: At base line, the mean (+/-SD) plasma norepinephrine concentration in the femoral vein was lower in the patients with the postural tachycardia syndrome than in the normal subjects (135+/-30 vs. 215+/-55 pg per milliliter [0.80+/-0.18 vs. 1.27+/-0.32 nmol per liter], P=0.001). Norepinephrine spillover in the arms increased to a similar extent in the two groups in response to each of the three stimuli, but the increases in the legs were smaller in the patients with the postural tachycardia syndrome than in the normal subjects (0.001+/-0.09 vs. 0.12+/-0.12 ng per minute per deciliter of tissue [0.006+/-0.53 vs. 0.71+/-0.71 nmol per minute per deciliter] with the cold pressor test, P=0.02; 0.02+/-0.07 vs. 0.23+/-0.17 ng per minute per deciliter [0.12+/-0.41 vs. 1.36+/-1.00 nmol per minute per deciliter] with nitroprusside infusion, P=0.01; and 0.008+/-0.09 vs. 0.19+/-0.25 ng per minute per deciliter [0.05+/-0.53 vs. 1.12+/-1.47 nmol per minute per deciliter] with tyramine infusion, P=0.04). CONCLUSIONS:
|
Authors | G Jacob, F Costa, J R Shannon, R M Robertson, M Wathen, M Stein, I Biaggioni, A Ertl, B Black, D Robertson |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 343
Issue 14
Pg. 1008-14
(Oct 05 2000)
ISSN: 0028-4793 [Print] United States |
PMID | 11018167
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Nitroprusside
- Norepinephrine
- Tyramine
|
Topics |
- Adult
- Arm
(blood supply)
- Autonomic Nervous System Diseases
(complications)
- Blood Pressure
- Case-Control Studies
- Cold Temperature
- Female
- Femoral Vein
- Heart Rate
- Humans
- Leg
(blood supply, innervation)
- Male
- Nitroprusside
(pharmacology)
- Norepinephrine
(blood, pharmacokinetics)
- Posture
(physiology)
- Reference Values
- Sympathetic Nervous System
- Tachycardia
(blood, etiology, physiopathology)
- Tyramine
(pharmacology)
|