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Effects of a vasopressin antagonist in women with dysmenorrhea.

Abstract
We compared menstrual pain, uterine contractility and blood circulation, and plasma concentrations of vasopressin and prostaglandin F(2alpha) metabolite in women with versus without primary dysmenorrhea, and determined the effects of a vasopressin antagonist, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin (Atosiban), on these parameters. Our results do not support the contention that vasopressin is involved in the etiology of dysmenorrhea, plasma concentrations of vasopressin being similar in dysmenorrheic women and controls, and the vasopressin antagonist Atosiban having no effect on menstrual pain, intrauterine pressure or uterine artery pulsatility index in dysmenorrheic women.
AuthorsL Valentin, P Sladkevicius, H Kindahl, A Broeders, K Marsal, P Melin
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 50 Issue 3 Pg. 170-7 ( 2000) ISSN: 0378-7346 [Print] Switzerland
PMID11014949 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2000 S. Karger AG, Basel
Chemical References
  • Hormone Antagonists
  • atosiban
  • Vasopressins
  • Dinoprost
  • Vasotocin
Topics
  • Adult
  • Blood Flow Velocity (drug effects)
  • Cross-Over Studies
  • Dinoprost (metabolism)
  • Double-Blind Method
  • Dysmenorrhea (drug therapy, metabolism, physiopathology)
  • Female
  • Hormone Antagonists (therapeutic use)
  • Humans
  • Uterine Contraction (drug effects)
  • Uterus (blood supply, drug effects)
  • Vasopressins (antagonists & inhibitors, metabolism)
  • Vasotocin (analogs & derivatives, therapeutic use)

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