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Significantly increased lesion size by using the near-infrared photosensitizer 5,10,15,20-tetrakis (m-hydroxyphenyl)bacteriochlorin in interstitial photodynamic therapy of normal rat liver tissue.

AbstractBACKGROUND AND OBJECTIVE:
Penetration of tissues by activating light ultimately limits the size of the lesions achievable in interstitial photodynamic therapy. Measurements of the wavelength-dependence of tissue optical properties suggest that substantial improvements may be possible, particularly in pigmented organs such as the liver, by using drugs absorbing at near infrared wavelengths.
STUDY DESIGN/MATERIALS AND METHODS:
In this study, the extent of light induced necrosis with the photosensitive agents Photofrin (activated at 632 nm), meta-tetra(hydroxyphenyl)chlorin (mTHPC) (activated at 652 nm) and 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (mTHPBC) (activated at 740 nm) are compared in normal rat liver. Interstitial irradiation of mTHPBC-sensitized liver tissue resulted in significantly larger necrotic areas than irradiation of Photofrin and mTHPC-sensitised livers.
CONCLUSION:
The results illustrate the advantage of near-infrared photosensitizer activation and point to a specific role for mTHPBC in the interstitial treatment of liver tumours.
AuthorsJ P Rovers, M L de Jode, M F Grahn
JournalLasers in surgery and medicine (Lasers Surg Med) Vol. 27 Issue 3 Pg. 235-40 ( 2000) ISSN: 0196-8092 [Print] UNITED STATES
PMID11013385 (Publication Type: Evaluation Studies, Journal Article)
CopyrightCopyright 2000 Wiley-Liss, Inc.
Chemical References
  • 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin
  • Mesoporphyrins
  • Photosensitizing Agents
  • Porphyrins
  • Dihematoporphyrin Ether
  • temoporfin
Topics
  • Animals
  • Dihematoporphyrin Ether (therapeutic use)
  • Laser Therapy
  • Liver (pathology)
  • Male
  • Mesoporphyrins (therapeutic use)
  • Necrosis
  • Photochemotherapy (adverse effects, methods)
  • Photosensitizing Agents (therapeutic use)
  • Porphyrins (therapeutic use)
  • Random Allocation
  • Rats
  • Rats, Wistar

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