Abstract |
The purpose of this study was to evaluate alpha 1-acid glycoprotein (AGP) concentrations in tumor-bearing and healthy cats. The hypothesis of the present study was that AGP concentrations would be significantly increased in tumor-bearing cats. Serum from 51 healthy and 97 tumor-bearing, client-owned cats was harvested at the time of presentation and stored at -80 degrees C until assayed. Cats with measurable, histologically confirmed malignancies, and healthy cats of similar ages were included. Serum was assayed for AGP concentration by using a radial immunodiffusion method. AGP concentrations were significantly (P = .0051) higher in tumor-bearing (763 +/- 595 microg/mL; mean +/- SD) when compared to healthy cats (501 +/- 377 microg/mL; mean +/- SD). Of the tumor-bearing cats, 35 had carcinomas, 33 had sarcomas, and 26 had discrete, round cell tumors. AGP concentrations were 645 +/- 62 microg/mL, 660 +/- 540 microg/mL, and 967 +/- 860 microg/mL, respectively, and there were no significant differences among the groups.
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Authors | K A Selting, G K Ogilvie, S E Lana, M J Fettman, K L Mitchener, R A Hansen, K L Richardson, J A Walton, M A Scherk |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2000 Sep-Oct
Vol. 14
Issue 5
Pg. 503-6
ISSN: 0891-6640 [Print] United States |
PMID | 11012113
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Carcinoma
(blood, pathology, veterinary)
- Carcinoma, Small Cell
(blood, pathology, veterinary)
- Cat Diseases
(blood, pathology)
- Cats
(blood)
- Immunodiffusion
(veterinary)
- Orosomucoid
(analysis)
- Regression Analysis
- Sarcoma
(blood, pathology, veterinary)
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