Acular as a single agent for use as an antimiotic and anti-inflammatory in cataract surgery.

Abstract

PURPOSE:

To assess the safety and effectiveness of ketorolac tromethamine 0. 5% (Acular) as a cost-efficient single agent to prevent intraoperative miosis and postoperative inflammation in cataract surgery.

METHODS:

Both eyes of 26 patients were randomized to receive Acular preoperatively and postoperatively or flurbiprofen sodium (Ocufen) preoperatively and prednisolone acetate 1% (Pred Forte) postoperatively. Time scheduled between procedures was from 2 weeks to 1 month. Pupil dilation was measured preoperatively, intraoperatively, and at the end of surgery. Cell and flare were measured 1 day, 1 week, and 1 month postoperatively.

RESULTS:

A comparison of the Acular and the Ocufen/Pred Forte groups (n=22) showed no statistically significant differences in dilation (preoperative versus postpostoperative) or cell and flare postoperatively.

CONCLUSIONS:

Using Acular as a single agent was as effective as the combination of preoperative Ocufen and postoperative Pred Forte in preventing intraoperative miosis and postoperative inflammation in cataract surgery. The use of Acular as a single agent could save the expense of using separate anti-inflammatory and antimiotic preparations preoperatively and postoperatively, enhancing convenience for the surgeon and surgical facility.

• Authors: R W Snyder, R W Siekert, J Schwiegerling, E Donnenfeld, P Thompson
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 26 Issue 8 Pg. 1225-7 (Aug 2000) ISSN: 0886-3350 [Print] United States
• PMID: 11008052 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Glucocorticoids
• Ophthalmic Solutions
• Ketorolac Tromethamine
• Flurbiprofen
• prednisolone acetate
• Prednisolone

Topics

• Anterior Chamber (pathology)
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Cataract Extraction (adverse effects)
• Cell Count
• Drug Administration Schedule
• Drug Therapy, Combination
• Endophthalmitis (etiology, pathology, prevention & control)
• Flurbiprofen (administration & dosage)
• Glucocorticoids (administration & dosage)
• Humans
• Ketorolac Tromethamine (administration & dosage)
• Miosis (etiology, prevention & control)
• Ophthalmic Solutions
• Postoperative Period
• Prednisolone (administration & dosage, analogs & derivatives)
• Preoperative Care
• Safety