| Abstract | PURPOSE: To report a case of systemic corticosteroid toxicity resulting from topical and periocular therapy. METHODS: Treatment and follow-up of an 11-year-old male with uveitis are illustrated. Initial presentation of the patient was bilateral iridocyclitis, for which he was treated with prednisolone acetate 1% every 2 hours for 6 months. Subsequently, posterior uveitis developed, necessitating posterior subtenon injections. RESULTS: After initial topical corticosteroid therapy, the patient developed a cushingoid habitus accompanied by increased lanugo hair, acanthosis nigricans, posterior subcapsular lens opacities, and increased intraocular pressure. Cushingoid stigmata worsened after administration of posterior subtenon injection of corticosteroids. The patient's truncal obesity worsened, and his linear growth stopped. CONCLUSIONS: Systemic toxic effects may develop as a result of topical and local use of ophthalmic corticosteroid preparations in susceptible patients. |
| Authors | U Ozerdem, L Levi, L Cheng, M K Song, C Scher, W R Freeman
(Affiliation: Shiley Eye Center, University of California, San Diego, La Jolla, California 92093-0946, USA.)
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| Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 130
Issue 2
Pg. 240-1
(Aug 2000)
ISSN: 0002-9394 UNITED STATES |
| PMID | 11004305
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- Anti-Inflammatory Agents
- Glucocorticoids
- Prednisolone
- prednisolone acetate
- methylprednisolone acetate
- Methylprednisolone
|
| Topics |
- Acanthosis Nigricans
(chemically induced)
- Administration, Topical
- Anti-Inflammatory Agents
(adverse effects, therapeutic use)
- Cataract
(chemically induced)
- Child
- Cushing Syndrome
(chemically induced)
- Glucocorticoids
- Growth Disorders
(chemically induced)
- Hair Diseases
(chemically induced)
- Humans
- Injections
- Intraocular Pressure
(drug effects)
- Iridocyclitis
(drug therapy)
- Lens, Crystalline
(drug effects)
- Male
- Methylprednisolone
(adverse effects, analogs & derivatives)
- Obesity
(chemically induced)
- Ocular Hypertension
(chemically induced, drug therapy)
- Prednisolone
(adverse effects, analogs & derivatives, therapeutic use)
- Uveitis, Posterior
(chemically induced)
|
