Effect of a fixed valerian-Hop extract combination (Ze 91019) on sleep polygraphy in patients with non-organic insomnia: a pilot study.

Abstract

A pilot study with a fixed extract combination Ze 91019 of valerian and hop was conducted in 30 patients suffering from mild-moderate, non-organic insomnia. The diagnosis was confirmed by polysomnographic standard examinations. The patients were treated with 2 tablets in the evening. Each tablet contains 250 mg valerian extract and 60 mg hop extract. A polysomnographic re-examination after 2 weeks of treatment revealed declines in the sleep latency and the wake time. As a consequence the sleep efficiency increased. Sleep stage 1 (S1) was reduced and the slow wave sleep increased. In addition, the patients judged their being refreshed in the morning by assigning a rating of 1 to 6. They reported an improvement after 2 weeks of treatment. No adverse events were observed. Based on these findings a pivotal study can be designed.

• Authors: A Füssel, A Wolf, A Brattström
• Journal: European journal of medical research (Eur J Med Res) Vol. 5 Issue 9 Pg. 385-90 (Sep 18 2000) ISSN: 0949-2321 [Print] England
• PMID: 11003973 (Publication Type: Journal Article)

Chemical References

• Hova
• Hypnotics and Sedatives
• Plant Extracts

Topics

• Administration, Oral
• Humans
• Humulus
• Hypnotics and Sedatives (administration & dosage, therapeutic use)
• Pilot Projects
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Plants, Medicinal
• Polysomnography
• Sleep (drug effects)
• Sleep Initiation and Maintenance Disorders (drug therapy)
• Valerian