Abstract |
Tumor metastasis and invasion were shown to be inhibited by the 2-O-phosphorylated form (Asc2P) of L-ascorbic acid (Asc); intact Asc did not inhibit tumor invasion when added once, but appreciably inhibited it upon repeated addition. The anti-metastatic effect is attributable to a marked enrichment of intracellular Asc by Asc2P, subsequently dephosphorylated. Asc2P scavenged most of the intracellular reactive oxygen species ( ROSin), and notably inhibited production of matrix metalloproteases and cell motility. ROSin was decreased by Asc2P more markedly than by Asc added once. Thus, involvement of ROSin in tumor invasion and a potent anti-metastatic therapy by ROSin-decreasing agents are suggested.
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Authors | N Nagao, T Nakayama, T Etoh, I Saiki, N Miwa |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 126
Issue 9
Pg. 511-8
(Sep 2000)
ISSN: 0171-5216 [Print] Germany |
PMID | 11003563
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Free Radical Scavengers
- Reactive Oxygen Species
- ascorbate-2-phosphate
- Ascorbic Acid
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Topics |
- Animals
- Antineoplastic Agents
(pharmacokinetics, therapeutic use)
- Ascorbic Acid
(analogs & derivatives, metabolism, pharmacokinetics, therapeutic use)
- Cell Movement
(drug effects)
- Extracellular Matrix
(drug effects, metabolism)
- Female
- Fibrosarcoma
(drug therapy, prevention & control, secondary)
- Free Radical Scavengers
- Humans
- Melanoma, Experimental
(drug therapy, prevention & control, secondary)
- Mice
- Mice, Inbred C57BL
- Neoplasm Invasiveness
(prevention & control)
- Neoplasm Metastasis
(prevention & control)
- Oxidative Stress
(drug effects)
- Reactive Oxygen Species
(metabolism)
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