Hormones, growth factors and other plasma variables in relation to osteochondrosis.

Abstract

Osteochondrosis (OC) is a multifactorial disorder with endocrinological dysfunction and mineral imbalance having a role in pathogenesis. The present study focused on a possible relationship between insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D (1,25(OH)2D), cortisol, copper, zinc, calcium, ionised calcium, magnesium and phosphorus and 5 different postmortem and radiographical osteochondrosis scores of hock and stifle joints in foals age 0-11 months. Osteochondrosis-positive foals showed a significantly lower IGF-I activity than osteochondrosis-negative foals. PTH, 1,25(OH)2D, cortisol, copper, zinc and calcium also showed significant differences between osteochondrosis-positive and osteochondrosis-negative foals.

• Authors: Sloet van Oldruitenborgh-Ooste, J A Mol, A Barneveld
• Journal: Equine veterinary journal. Supplement (Equine Vet J Suppl) Issue 31 Pg. 45-54 (Nov 1999) United States
• PMID: 10999660 (Publication Type: Journal Article)

Chemical References

• Growth Substances
• Hormones
• Parathyroid Hormone
• Somatomedins
• Phosphorus
• Copper
• Calcitriol
• Magnesium
• Zinc
• Calcium
• Hydrocortisone

Topics

• Animals
• Animals, Newborn
• Breeding
• Calcitriol (blood)
• Calcium (blood)
• Copper (analysis, blood)
• Female
• Growth Substances (blood)
• Hindlimb
• Hormones (blood)
• Horse Diseases (blood)
• Horses
• Hydrocortisone (blood)
• Joint Diseases (blood, veterinary)
• Kidney (chemistry)
• Liver (chemistry)
• Magnesium (blood)
• Male
• Osteochondritis (blood, veterinary)
• Parathyroid Hormone (blood)
• Phosphorus (blood)
• Random Allocation
• Somatomedins (metabolism)
• Spleen (chemistry)
• Stifle
• Zinc (analysis, blood)