Lipid peroxide levels in chronic renal failure.

Abstract

To determine presence of oxidant stress in chronic renal failure and to evaluate the efficacy of vitamin E in its amelioration, we studied 34 patients (Group I, age 32.4 +/- 11 years, M:F 3:1) and 10 healthy controls (Group II, age 27.4 +/- 5 years, M:F 4:1). The difference in baseline values of lipid peroxide (nmol/ml) was statistically significant (Group I 4.19 +/- 1.69, Group II 1.87 +/- 1.39, p = 0.004). Values of vitamin E (mg/l) were also significantly lower in Group I as compared to Group II (12.18 +/- 4.27 vs. 19.32 +/- 2.03, p = 0.003). Serum lipid peroxide values decreased significantly after supplementation with 400 mg/day of vitamin E for six weeks in Group I (4.19 +/- 1.69 to 3.21 +/- 1.13, p = 0.053) but not in Group II (1.87 +/- 1.39 to 1.03 +/- 0.87). Levels of vitamin E increased in both the groups (Group I: 12.18 +/- 4.27 to 16.01 +/- 5.13, Group II: 19.32 +/- 2.03 to 23.21 +/- 1.94, p < 0.005). No significant difference was observed in values of serum creatinine and urea before and after intervention.

• Authors: A K Sharma, M Arora, A Goyle, R Jain, H Gupta, R Gupta
• Journal: The Journal of the Association of Physicians of India (J Assoc Physicians India) Vol. 47 Issue 3 Pg. 296-7 (Mar 1999) ISSN: 0004-5772 [Print] India
• PMID: 10999124 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Lipid Peroxides
• Vitamin E

Topics

• Adult
• Dietary Supplements
• Female
• Follow-Up Studies
• Humans
• Kidney Failure, Chronic (blood, drug therapy)
• Kidney Function Tests
• Lipid Peroxides (blood, metabolism)
• Male
• Middle Aged
• Reference Values
• Vitamin E (administration & dosage, blood)